The inventor

Dr. Didier Lapeyre is a cardiovascular surgeon with more than 45 years of experience in cardiovascular research. He has devoted his professional life to the design, development, and validation of innovative medical devices, including the artificial heart, for the benefit of patients.

“It has been more than 50 years that surgeons and patients, especially those under 65 years old, have been confronted with the cruel dilemma of having to choose in between the lifelong anticoagulation therapy required by current mechanical heart valves or a re-operation due to structural failure of  bioprosthesis valves.

Thanks to a trans-disciplinary cooperation between fluid dynamics experts, basic scientists in molecular biology of thrombosis, material experts and surgeons, the goal of a mechanical heart valve not requiring anticoagulation therapy may become a reality. This provides immense hope for thousands of patients suffering from heart valve disease, particularly young adults, children and women of child-bearing age worldwide.

I look forward to seeing soon in the clinical arena the Lapeyre-Triflo Mechanical Bioprosthesis.”

Didier Lapeyre, M.D., inventor of the Lapeyre-Triflo valve, Scientific & Medical advisor and Board Member


Dr. Didier Lapeyre is a cardiovascular surgeon, physiologist and inventor of prosthetic heart valves, ventricular assist devices, and artificial hearts.

In collaboration with DASSAULT-AVIATION, Dr. Lapeyre began to work on the first tri-leaflet heart valve in the 1980s and for several years led animal studies performed on his valve at TEXAS HEART INSTITUTE (Houston).

Previously, Dr. Lapeyre served as the designer, scientific and medical affairs director of the AEROSPATIAL total artificial heart program and worked at the French CNRS on the first totally artificial heart.

Dr. Lapeyre was trained by the pioneers of open heart surgery: Prof. Pierre Marion (Lyon, France), Dr. C. Walton Lillehei (Minneapolis, Minnesota), Dr. Denton A. Cooley (Houston, Texas), Dr. O.H. "Bud" Frazier (Houston, Texas), and the founders of the artificial heart research: Dr. William S. Pierce (Hershey, PA), Dr. Willem J. Kolff (Salt Lake City, Utah) and Dr. Tetsuzo Akutsu (Osaka, Japan).

Dr. Lapeyre has authored more than 30 scientific publications and is named inventor on more than 15 international patents.